Check Carefully (two)pentobarbital will lower the level or influence of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Solid CYP3A4 inducers could minimize suvorexant efficacy; if increased suvorexant dose necessary, do not exceed 20 mg/working daypentobarbital will decrease the extent or effect of disopyram